Used in dogs and cats for the treatment of acute and chronic inflammation of the external ear caused by bacterial, viral and yeast infections. Treat once a day for 7 days for acute infection and once a day for 14 days for chronic infection. Do not use in conjunction with other topical ear medications or cleaners.

Zymox Otic(formerly Zymox-E ® )contains 3 active enzymes that have been shown to be antibacterial,antifungal and antiviral. Zymox Otic is the natural antibiotic free treatment of choice proven to be highly effective against yeast and bacterial infections. Completely safe and harmless if ingested by the animal. The once a day protocol makes it very to use.

Warning: Do not use on punctured eardrums. Do not use on pregnant or lactating females.

Zymox is for the treatment of acute and chronic otitis externa due to bacterial, viral and yeast infections. Factors that predispose the ear to otitis externa:

• Excessive skin folds in ear
• Floppy ear carriage
• Stenosis
• Excessive hair
• Excessive cerumen production
• Suppressed immune system
• Systemic antibiotics

Zymox directions:

• Important: Do not clean ears before or during treatment!
• Apply liberally to fill ear canal
• Gently massage, working medication into infected area
• Permit pet to shake their head to remove excess
• Treat once a day for 7 days for acute infections
• Treat once a day for 14 days for chronic infection

- Post treatment flush is recomended to remove any residual product and accumulated dead skin cells.

- Do not use in conjunction with other topical ear medications or cleaners.

- Do not allow water in or near ear during treatment.

- Always consult your vet prior to any treatments for your pet.

Ingredients(Zymox Otic w/Hydrocortizone): Glycerin, Deionized Water, HydroxyPropyl Cellulose, Benzyl Alchohol, Potassium Iodide, Hydrocortisone, Dextrose, Propylene Glycol, Glucose Oxidase, Lysozyme, Lactoperoxidase, Lactoferrin.

Ingredients(Zymox Otic wo/Hydrocortizone): Glycerin, Deionized Water, Klucel, Benzyl Alchohol, Potassium Iodide, Dextrose, Propylene Glycol, Glucose Oxidase, Lysozyme, Lactoperoxidase, Lactoferrin.

How does Zymox Otic work?

Each enzyme has its own unique properties and when combined, pack a powerful antimicrobial punch. The 3 enzymes are derived naturally from milk products so they are 100% safe and gentle. For years, it has been known that milk has a natural ability to kill bacteria, viruses and yeast.

Only recently have the protein and enzyme system responsible been identified and reproduced. The three most effective are Lactoperoxidase, Lysozyme and Lactoferrin. Their antimicrobial activities are briefly listed below:

Lactoperoxidase - A known milk peroxidase which when combined together with hydrogen peroxide, thiocyanate and/or iodide produce a potent antibacterial system known as the Lactoperoxidase System. The hypohalous ions produced are either the hypothiocyanate ion or the hypoiodite ion. Both are bactericidal substances. Hypoiodite is also a known fungicidal agent. The antibacterial property of the Lactoperoxidase System is based upon inhabitation of vital bacterial metabolic enzymes brought on by their oxidation by hypothiocyanate or hypoiodite.

Lysozyme - An enzyme present in milk and egg whites.
Lysozyme kills bacteria by disrupting the formation of a glycosidic bond between the two components of peptidoglycan, a constituent of the bacterial cell wall. Lysozyme is effective against a number of bacteria including Escherichia coli and Salmonellae.

Lactoferrin - An iron binding protein. It is found naturally in cow and human milk, tears, saliva, seminal fluid and in some white blood cells.
Lactoferrin is only partially saturated with iron (5 to 30 percent) so it has a high affinity towards iron. Lactoferrin is bacteristatic against a wide range of microorganisms including gram-negative (coliforms) and gram-positive (staphylcoccus) bacteria. Lactoferrin has the potential to inhibit the growth of bacteria and kill them by depriving them of iron, which is vital for bacterial growth.